Welcome to the Holiday Inn Express Hotel & Suites Cape Girardeau. This newly built Cape Girardeau hotel opened in June 2005. Conveniently located at Interstate 55 and William St. (exit 96). The hotel is just minutes from Southeast Missouri State University, St. Francis Hospital, Southeast Missouri State Hospital, Doctors Park, Show Me Center, Procter & Gamble, Nordenia, Shawnee Park and Biokyowa. The Holiday Inn Express & Suites Cape Girardeau Hotel is midway between Memphis and St. Louis on I
